Seroxat CR Overdosage

Symptoms and Signs: A wide margin of safety is evident from available overdose information on SEROXAT.
Experience of SEROXAT in overdose has indicated that, in addition to those symptoms mentioned under Adverse Reactions, fever, blood pressure changes, involuntary muscle contractions, anxiety and tachycardia have been reported.
Patients have generally recovered without serious sequelae even when doses of up to 2000 mg have been taken alone. Events such as coma or ECG changes have occasionally been reported and, very rarely a fatal outcome, but generally when SEROXAT was taken in conjunction with other psychotropic drugs with or without alcohol.
Treatment: No specific antidote is known.
The treatment should consist of those general measures employed in the management of overdose with any antidepressant. Supportive care with frequent monitoring of vital signs and careful observation is indicated. Patient management should be as clinically indicated, or as recommended by the national poisons centre, where available.